
Publications

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Kim NM, Peng D, Sandoval NR: Nucleotide level characterization and improvement of L-arabinose and L-rhamnose inducible systems in E. coli using a high throughput approach. Nucleic Acids Research 2025; doi: doi.org/10.1093/nar/gkaf224
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Brooks RT, Lisa Morici, Sandoval NR: Cell Free Bacteriophage Synthesis from Engineered Strains Improves Yield. ACS Synth Biol 2023; doi: 10.1021/acssynbio.3c00239.
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Joseph RC, Sandoval NR: Single and multiplexed gene repression in solventogenic Clostridium via Cas12a-based CRISPR interference. Synthetic and Systems Biotechnology 2023; 8 (1), 148-156. doi: 10.1016/j.synbio.2022.12.005.
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Kim NM, Sinnott RW, Rothschild LN, Sandoval, N. R., Elucidation of sequence-function relationships for an improved biobutanol in vivo biosensor in E. coli. Front. Bioeng. Biotechnol 2022; 10. doi: 10.3389/fbioe.2022.821152
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Synoground B, McGraw C, Elliott K, Leuze C, Roth J, Harcum S, Sandoval NR: Transient ammonia stress on Chinese hamster ovary (CHO) cells yield alterations to alanine metabolism and IgG glycosylation profiles in a cell line age-dependent manner. 2021 Biotech J. doi: 10.1002/biot.202100098
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McGraw CM, Peng D, Sandoval NR: Synthetic biology approaches: The next tools for improved protein production from CHO cells. Curr Op Chem Eng 2020; 30, 26-33. doi: 10.1016/j.coche.2020.06.003
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Payne M, Lou Y, Zhang X, Sahiner N, Sandoval NR, Shantz D, Grayson S: Comparison of Crosslinked Branched and Linear Poly(ethylene imine) Microgel Microstructures and Its Impact in Antimicrobial Behavior, Copper Chelation, and Carbon Dioxide Capture. ACS Applied Polymer Materials 2020; 2 (2), 826-836. doi: 10.1021/acsapm.9b01101
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Kim NM, Sinnott RW, Sandoval NR: Transcription Factor-Based Biosensors and Inducible Systems in Non-Model Bacteria. Curr Op Biotech 2020; 64:39-46. doi: 10.1016/j.copbio.2019.09.009
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Mkam Tsengam IK, Marzhana O, Shepherd L, Sandoval NR, He J, Kelly E, John VJ: Clusters of Nanoscale Liposomes Modulate the Release of Encapsulated Species and Mimic the Compartmentalization Intrinsic in Cell Structures. ACS Applied Nano Materials 2019; 2, 11, 7134-7143.
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Joseph RC, Kim NM, Sandoval NR: Recent developments in the synthetic biology tool kit in Clostridium. Frontiers in Microbiology 2018; 9, 154. doi: 10.3389/fmicb.2018.00154
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Rohlhill J, Sandoval NR*, Papoutsakis ET*. Sort-Seq Approach to Engineering a Formaldehyde-Inducible Promoter for Dynamically Regulated Escherichia coli Growth on Methanol. ACS Synth Biol. 2017. doi: 10.1021/acssynbio.7b00114. (*co-corresponding authors)
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Long CP, Au J, Sandoval NR, Gebreselassie NA, Antoniewicz MR. Enzyme I facilitates reverse flux from pyruvate to phosphoenolpyruvate in Escherichia coli. Nature Communications. 2017; 8:14316. doi: 10.1038/ncomms14316
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Sandoval NR, Papoutsakis ET: Engineering membrane and cell-wall programs for tolerance to toxic chemicals: Beyond solo genes. Curr Opin Microbiol 2016, 33:56-66.
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CP Long, JE Gonzalez, NR Sandoval, MR Antoniewicz: Characterization of physiological responses to 22 gene knockouts in Escherichia coli central carbon metabolism, Metab eng, 37 (2016).
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Cordova LT, Lu J, Cipolla RM, Sandoval NR, and Antoniewicz MR: Simultaneous utilization of glucose and xylose by an evolved Thermus thermophilus strain elucidated by 13C metabolic flux analysis and genome sequencing. Metab eng, 37 (2016) 63-71.
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Sandoval NR, Venkataramanan KP, Groth TS, Papoutsakis ET: Genome sequencing identifies Spo0A inactivation in Clostridium pasteurianum as imparting enhanced tolerance to crude glycerol and increased growth-associated butanol production. Biotechnol Biofuels, 8 (2015) 227.
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Gaida SM*, Sandoval NR*, Nicolaou SA, Chen Y, and Papoutsakis ET: Expression of heterologous sigma factors enables functional screening of metagenomic and heterologous genomic libraries. Nat Comm 2015, 6:7045. (*Equal contribution)
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Whitaker WB, Sandoval NR, Bennett RK, and Papoutsakis ET: Synthetic methylotrophy: engineering the production of biofuels and chemicals based on the biology of aerobic methanol utilization. Curr Opin Biotechnol. (2015) 33:165–175.
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Glebes TY, Sandoval NR, Gillis JH and Gill RT: Comparison of genome-wide selection strategies to identify furfural tolerance genes in Escherichia coli. Biotechnol Bioeng. (2015) 112:129-140.
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Glebes TY, Sandoval NR, Reeder PJ, Schilling KD, Zhang M, Gill RT: Genome-wide mapping of furfural tolerance genes in Escherichia coli. PLoS One. (2014) 9(1): e87540.
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Sandoval NR, Kim JYH, Reeder P, Glebes TY, Aucoin HR, Warner JR, and Gill RT: A Strategy for Directing Combinatorial Genome Engineering in E. coli. PNAS 26 (2012) 10540-10545.
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Sandoval NR, Mills TY, Zhang M, and Gill RT: Elucidating acetate tolerance in E. coli using a genome-wide approach. Metab Eng. 13 (2011) 214-224.
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Mills TY*, Sandoval NR*, and Gill RT: Cellulosic hydrolysate toxicity and tolerance mechanisms in Escherichia coli. Biotechnol Biofuels (2009) 2:26. (*Equal contribution)
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Gall S, Lynch MD, Sandoval NR, and Gill RT: Parallel mapping of genotypes to phenotypes contributing to overall biological fitness. Metab Eng. 10 (2008) 382-393.
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Warnecke TE, Lynch MD, Karimpour-Fard A, Sandoval NR, and Gill RT: A genomics approach to improve the analysis and design of strain selections. Metab Eng 10 (2008) 154-165.
